Probiota Asia 2018

Scientific Frontiers: Gold kiwifruit study takes top spot at Probiota Asia 2018

By Gary Scattergood contact

- Last updated on GMT

A phase-2 clinical trial is now underway.
A phase-2 clinical trial is now underway.
A randomised, cross-over study that investigated the impact of Actazin green and Livaux gold kiwifruit supplements on faecal microbial composition and metabolites in healthy and functionally constipated (FC) participants was the top-rated poster at our Probiota Asia summit.

The intervention combinations included placebo, Actazin L (600 mg/d), Actazin H (2400 mg/d) and Livaux (2400 mg/d) for 28 days, with a washout period between each treatment phase.

The most notable finding was that in the FC group, Faecalibacterium prausnitzii​ abundance significantly increased from 3.4% to 7.0 % following Livaux supplementation, with eight of the nine participants showing a net increase.

Low amounts of F. prausnitzii​ have been associated with a range of intestinal disorders, including irritable bowel syndrome (IBS), atopy, diabetes and inflammatory bowel diseases such as Crohn’s disease and ulcerative colitis.

The study was published in the Journal of Nutritional Science ​and led by scientists from Plant and Food Research.

Both products are marketed by Anagenix, and Elizabeth Tay from the firm addressed delegates at the Singapore summit.

She said: “Depleted  concentrations  of  F.  prausnitzii    appears  to  be  undesirable.  An  increase  in  F.  prausnitzii  could  confer  beneficial  outcomes  to  the  host  as  F.  prausnitzi ihas  been  shown  to  exert  anti-inflammatory  effects  in  many  studies  and  is  a  butyrate  producer,  which  has  protective  functions  and  health  benefits  in  the  gut.

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Efficient and effective 

“F.  prausnitzii  is  highly  sensitive  to  oxygen,  making  formulation  and  storage  as  a  probiotic  difficult.    The  targeted  prebiotic  effect  of  Livaux,  which  is  believed  to  come  from  the  dietary  fibre    and  phytochemicals/polyphenols  that  naturally  occur  in  gold  kiwifruit,  provides  an  efficient  and  effective  means  for  increasing  F.  prausnitzii  levels,  which  might  otherwise  be  difficult  to  modulate.”

A phase-2 clinical trial is now underway. The Primary  objective is an  improvement  of  one complete  spontaneous  bowel  movement  (CSBM)/week  in  participants  who  normally  have  ≤  3  CSBM/week  as  assessed  by  daily  bowel  habits  diary.   

Secondary objectives include stool  form,  time  of  bowel  movements, quality  of  life,  constipation  symptoms and change  in  gut  microbiome  as  assessed  by  faecal  sample  analysis.

To  date,  25%  of  participants  have  completed  the  trial.   

They are working towards a  full  completion  date,  including  data  analysis,  of  April  2019  with  journal  publication  to  follow.

The Scientifc Frontiers poster competition was judged by our expert Scientific Committee.

 

Source: Journal of Nutritional Science

Journal of Nutritional Science ​(2017), vol. 6, e52

"Consumption of kiwifruit capsules increases Faecalibacterium prausnitzii abundance in functionally constipated individuals: a randomised controlled human trial"

Authors: Paul Blatchford, et al.

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