Blend of ayurvedic ingredients reduces symptoms of knee osteoarthritis – Indian trial

The ingredient E-OA-07 is a blend of seven ayurvedic ingredients, such as ashwagandha, shyonaka (oroxylum indicum), and shunthi (zingiber officinale). 

The trial looked at the efficacy of E-OA-07 at 1,000mg in alleviating the symptoms of moderate-to-severe cases of knee osteoarthritis.

Using the E-OA-07 manufactured and sold by Enovate Biolife under the tradename Lanconone, the results of the trial were recently published in The Journal of Pain Research. ​

Forty-four participants aged 40 to 65 completed the randomised, double-blind, placebo-controlled study.  

To qualify for the study, they needed to have a history of joint paint for at least three years, body mass index within the range of 25 to 29.9, and knee joint pain of at least 60, based on a 100-point pain visual-analogue scale score. 

During the study, the treatment group had to take two capsules of E-OA-07, each 500mg, after breakfast. 

To find out the effects of E-OA-07, the participants’ pain scores were then measured based on the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and it was found that the treatment group had a lower pain score. 

For instance, the mean pain score of the treatment group had dropped from 14.95 ± 1.72 to 8.14 ± 3.83. 

As for the placebo group, the mean pain score did not show drastic change, hovering between 14.87 ± 1.87 and 14.30 ± 3.81. 

The researchers noted that the effects of E-OA-07 became significant from the 4th week of the study.  

In addition, by the end of the study period, there was a clinically relevant change of 45.55%, 45.91% and 38.19% for pain, stiffness and physical function respectively.

“Overall, results of the present study support the effectiveness and safety of E-OA-07 in individuals suffering from symptoms of ​knee osteoarthritis​,” ​the researchers said. 

Stiffness score ​

Besides the improvement in pain score, the stiffness score was also reduced in the treatment group as compared to the placebo group. 

For instance, the stiffness score dropped from 5.38 ± 1.02 to 2.91 ± 1.51 for the treatment group. 

For the placebo group, the score, however, increased from 5.17 ± 1.61 to 5.44 ± 1.62. 

Source: Journal of Pain Research 

Effect Of E-OA-07 On Improving Joint Health and Mobility In Individuals With Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group ​

Study​

DOI: http://doi.org/10.2147/JPR.S231237​

Authors: Shalini Srivastava, et al ​