Breaking News on Supplements, Health & Nutrition - Asia PacificEU edition | US edition

News > Research

Read more breaking news



Curcumin helps to effectively ease inflammatory bowel disease: China mouse study

By Gary Scattergood+

Last updated on 14-Feb-2017 at 05:38 GMT2017-02-14T05:38:29Z

Curcumin helps to effectively ease inflammatory bowel disease: China mouse study

Curcumin can help suppress the activation of dendritic cells (DCs), which play a pivotal role in the progression of inflammatory bowel disease, research from China has discovered.

Academics at Jiangxi University assessed if curcumin could represent a viable treatment alternative or adjunctive therapy in the management of chronic inflammatory bowel disease.

Writing in the journal Frontiers of Pharmacology, they reported their latest study found that he total number of DCs in colitis-induced mice was lower among those treated with curcumin.

In addition, curcumin was found to regulate costimulatory molecules, which are specific markers of mature DCs, as well as cytokine expression in colonic tissues.

“In the development of DCs, the expression of cytokines is indispensable to the microenvironment of maturation,” wrote the researchers.

Their work explored the mechanism of curcumin treated experimental colitis by observing activation of DCs via the JAK/STAT/SOCS signalling pathway.

“Experimental colitis was induced by 2, 4, 6-trinitrobenzene sulfonic acid (TNBS). After seven days treatment with curcumin, its therapeutic effect was verified by decreased colonic weight, histological scores, and remitting pathological injury,” they wrote.

Reduced inflammation

Thirty-two mice were randomly assigned to four groups with eight mice in each group: the normal group, the TNBS group, the TNBS and curcumin group, and the TNBS and mesalazine group. Mesalazine is an anti-inflammatory drug used to treat inflammatory bowel disease

“Treatment with curcumin and mesalazine restrained…pathological symptoms and histo-progressive restoration, reduced inflammatory cell infiltration in the mucosa and submucosa, and maintained the integrity of colonic mucosa,” the researchers reported.

While ulceration, hyperaemia, and edema in local colonic mucosa were observed in mice without treatment, these conditions were considerably better in colitis mice treated with curcumin and mesalazine.

The researchers added: “All results demonstrated that curcumin effectively treated experimental colitis.

They concluded that curcumin suppressed the activation of DCs by modulating the JAK/STAT/SOCS signalling pathway to restore "immunologic balance and to treat experimental colitis in an effective manner."

“These results hinted that curcumin potentially prevent the chronicity of colitis. Certainly, the results should be verified repeatedly and explored [with reagrd to] their pathway in colitis treatment in the next work,” they added.


Source: Frontiers of Pharmacology.

“Curcumin Suppressed Activation of Dendritic Cells via JAK/STAT/SOCS Signal in Mice with Experimental Colitis”

Authors, Hai-Mei Zhao, et al.

Related products

Key Industry Events


Access all events listing

Our events, Shows & Conferences...

Live Supplier Webinars

Polyphenols tipped to become the way to innovate in Sports Nutrition
Orally bioavailable standardized botanical derivatives in sport nutrition: special focus on recovery in post-intense physical activities
Collagen in motion: move freely and keep your injuries in check
Leading manufacturer of gelatine and collagen peptides
Life’s too short for slow proteins. Whey proteins hydrolysates: Fast delivery for enhanced performance
Arla Foods Ingredients
What it Takes to Compete and Win in Today’s Sports Nutrition Market
Sports Nutrition Snapshot: Key regional drivers and delivery format innovations
William Reed Business Media
Gutsy performance: How can microbiome modulation help athletes and weekend warriors
William Reed Business Media
Pushing the boundaries: Where’s the line between ‘cutting edge nutrition’ and doping
William Reed Business Media
Alpha & Omega in Sports Nutrition – Using Omega 3’s and A-GPC to improve performance and recovery.
KD Pharma

On demand Supplier Webinars

High-amylose maize starch may reduce the risk of type 2 diabetes: what does this qualified health claim mean?
Explaining bio-hacking: is there a marketing opportunity for food companies?
William Reed Business Media
Personalized Nutrition – how an industry can take part in shaping the future of Nutrition
BASF Nutrition & Health
Find out Nutritional and ingredient lifecycle solutions and strategies!
Is the time rIpe for I-nutrition?
William Reed Business Media
The Advantage of Outsourcing Fermentation-based Manufacturing Processes
Evonik Health Care
All supplier webinars