Diet, microbiome and immunity; Scientists pinpoint gut microbe that triggers immune-signalling ‘cascade’

By Gary Scattergood contact

- Last updated on GMT

The new study elucidates the precise molecular cascade behind diet and immune health. ©Getty Images
The new study elucidates the precise molecular cascade behind diet and immune health. ©Getty Images

Related tags: microbiome, Nutrition

New research in mice appears to show how diet alters the immune system by downregulating inflammation through a gut microbe.

Researchers say the findings, published in Nature​, offer a unifying explanation for the complex interplay between diet, gut microbiota and immune function.

They are the result of collaboration among scientists at Harvard Medical School, Brigham and Women’s Hospital, Seoul National University, and Monash University in Australia.

The research has pinpointed a microbial molecule called B. fragilis​ that sets off an immune-signalling cascade triggered by the host’s diet of a metabolic breakdown of branch-chained amino acids in the mouse gut.

The multistep pathway begins with B. fragilis​ taking up the branch-chained amino acids and then converting them by a specific enzyme into sugar-lipid molecules.

These molecules also have branched chains that are then spotted and picked up by a class of immune-signalling cells known as antigen-presenting cells.

These, in turn induce natural killer T (NKT) cells to exercise their immunoregulatory response through upregulating inflammation-controlling genes and immune-regulatory chemicals.

Furthermore, the team found that B. fragilis​ alters the structure of the sugar-lipid molecules that it metabolises and renders them better capable of binding to receptors on specific immune cells and initiating a signalling cascade that culminates in downregulating inflammation.

NKT cells line the human gastrointestinal tract, the lungs and are also found in the liver and spleen and likely play a significant role in immune regulation and are implicated in a range of inflammatory conditions including ulcerative colitis, and to a possible role in airway inflammatory conditions, such as asthma.

Professor Jamie Rossjohn, ARC Laureate Fellow at the Monash Biomedicine Discovery Institute, said: “This work offers a great example of trans-disciplinary discovery-based research aimed at answering a major question in biomedical sciences, namely how the immune system can be modulated by the interplay between diet and the microbiota.”

Precise action

While scientists have surmised for a long time that diet plays a role in immune health, the new study elucidates the precise molecular cascade behind diet and immune health, said study senior author Dennis Kasper​, professor of immunology at Harvard Medical School.

“We have shown how diet affects the immune system through a microbe mediator in the gut, and this is a really striking example of the diet-microbiota-immunity triad at play,” ​Kasper said. “What this work really does is provide a step-by-step pathway from beginning to end that explains how and why this triad works and how diet ultimately affects the immune system.”

Study coinvestigator Seung Bum Park, professor of chemistry at Seoul National University, synthesized and the Harvard team tested 23 different configurations of the microbe-made immunomodulatory molecule to determine how each one interacts with the immune cells that regulate inflammation.

“Our new work demonstrates that the branching of the lipid structure induces a very different response—the branching in the structure induces an anti-inflammatory rather than a proinflammatory response,” ​Professor Kasper said.

The findings offer the hope that inflammatory diseases mediated by these NKT cells could one day be treated with inflammation-dampening microbial molecules made in the lab, the researchers said.

Source: Nature

“Host immunomodulatory lipids created by symbionts from dietary amino acids.”

DOI: 10.1038/s41586-021-04083-0

Authors: Dennis L Kasper, et al

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