The study, led by Pusan National University, investigated the protective effects of a chondroitin sulfate-rich extract (CSE) from skate cartilage against liver damage caused by lipopolysaccharide (LPS) in mice.
Researchers compared how the CSE fared compared with chondroitin sulfate (CS) from shark cartilage — which had previously been shown to protect against inflammation of the liver.
They found the CSE mice were protected against LPS-induced liver damage due to the CSE reducing oxidative stress. These beneficial effects were noted to be comparable to those of CS.
Harmful enzymes released into the circulatory system in the event of liver structure were noticeably alleviated by the CSE, showing that “skate CSE has a preventative effect against LPS-induced liver damage”.
Additionally, both the CSE and CS were found to be able to lower LPS-induced liver inflammation in the mice by downregulating the “gene expression of pro-inflammatory cytokines and enzymes”.
At the same time, the CSE was said to be able to “effectively ameliorate LPS-induced hyperlipidemia”, which often accompanies infectious and inflammatory diseases; the extract was shown to have significantly lowered serum lipid levels.
Source: Marine Drugs
“Chondroitin Sulfate-Rich Extract of Skate Cartilage Attenuates Lipopolysaccharide-Induced Liver Damage in Mice”
Authors: Yeong Ok Song, et al.