Diet high in vitamins, fibre and minerals leads to reduced peripheral artery disease risk: Population study

By Cheryl Tay

- Last updated on GMT

Diet quality, plasma vitamin levels, and TFAs were found to be related to the risk of PAD. ©Getty Images
Diet quality, plasma vitamin levels, and TFAs were found to be related to the risk of PAD. ©Getty Images

Related tags Nutrition

Diet, plasma vitamins and, trans fatty acids (TFAs) are linked to the risk of peripheral artery disease (PAD), according to researchers China.

PAD is a debilitating chronic cardiovascular disease brought on by atherosclerotic plaques developing in the arteries of the body’s lower extremities. Apart from ageing, smoking, hypertension, hypercholesterolemia, diabetes and chronic kidney failure are known risk factors for PAD.

However, compared to other heart diseases, little is known about the impact of one’s diet on PAD risk, with few prior studies having been published on the topic.

As such, researchers at the Chinese Academy of Sciences in Beijing conducted a study to explore the relationship between dietary patterns, plasma vitamins and TFAs and PAD risk.

Using 1999 — 2002 data from the National Health and Nutrition Examination Survey (NHANES), they found that of the 4,864 participants (2,482 men and 2,382 women), 269 had prevalent PAD.

Diet and disease

They wrote: "PAD patients had significantly higher serum concentrations of trans 9-octadecenoic acid and trans 9, trans 12-octadienoic acid, as well as lower plasma levels of vitamin D, retinol, retinyl stearate and retinyl palmitate."

They also discovered three dietary patterns responsible for 56.8% of the variance in dietary nutrient intake: one was characterised by fatty acids and cholesterol, another by fibre, minerals and vitamins, and the last by polyunsaturated fatty acids (PUFAs).

After adjusting for age, race, cholesterol level, energy intake, and diabetes, hypertension and smoking status, the researchers observed that those whose diets were high in fatty acids and cholesterol faced a higher PAD risk, while those whose diets were high in either fibre, minerals and vitamins or PUFAs faced a lower PAD risk.

Prevention and delay

The researchers stated that diet quality, plasma vitamin levels, and TFAs were indeed related to the risk of PAD, adding that such factors could be manipulated to delay or even prevent the disease.

They concluded: "Our results provide information on the association between plasma vitamins and TFAs and the likelihood of PAD.

"We have found that dietary factors (either via consumption or plasma concentration) are independently associated with the likelihood of PAD.

"The impact of the dietary items on preventing or delaying the clinical progression of PAD should be investigated in intervention trials."


Source: Lipids in Health and Disease

"Dietary patterns, plasma vitamins and Transfatty acids are associated with peripheral artery disease"

Authors: Mohsen Mazidi, et al.

Related news

Show more

Related products

Immune Training for Everyday Health

Immune Training for Everyday Health

Recorded the 30-Aug-2023 | Webinar

It is relatively well understood that the immune system remembers the bacteria and viruses that it has previously encountered, protecting us when we come...

Full Vegan Protein Ingredients Solution

Full Vegan Protein Ingredients Solution

Content provided by Ingredients4u AG | 24-Jul-2023 | Product Brochure

Plant-based products have always been a hot topic in the market, the plant-based food market was valued at $29.4 billion in 2020.

Follow us


View more


Nutra Champions Podcast

Nutra Champions Podcast