COVID-19 protease inhibitor search: Chinese researchers to screen one million functional foods ligands

By Tingmin Koe contact

- Last updated on GMT

Quercetrin is rich in non-fermented tea such as green tea. ©Getty Images
Quercetrin is rich in non-fermented tea such as green tea. ©Getty Images

Related tags: COVID-19, Functional foods, China

A group of Chinese researchers is screening one million functional foods ligands (or molecules) in their search for the ones that could potentially inhibit the main protease of COVID-19.

The screening has already reached the halfway mark and the researchers hope to complete the screening on the remaining 500,000 ligands in the next two months, researcher Dr Binglin Li from the Northwest University, Xi’an, told NutraIngredients-Asia.

In fact, the present project is an extension of their findings published in the Journal of Food Biochemistry ​last month.

That study screened 10,870 ligands from 12 types of functional foods, including carbohydrates, fatty acids, phospholipids, vitamin, flavonoids, and curcumin etc.

Using molecular docking methods, the virtual screening found that ligands with an aromatic ring structure and double bonds have a stronger affinity with the main protease of COVID-19.

Examples of ligands with such structures are flavonoids, which is also why Dr Li and his colleagues concluded that quercetrin – a type of flavonoid – and its isomers/analogs/derivatives are the best inhibitors.

Quercetrin is rich in non-fermented tea, including green and white tea, Dr Li said.

What findings?

The study, supported by the Key Research and Invention Program in Shaanxi Province of China, also measured the affinity of two FDA approved drugs – conivaptan and azelastine – with the COVID-19 protease.

The molecular docking results showed that flavonoids have a better binding affinity with the main protease of COVID-19, when compared to conivaptan and azelastine.

For flavonoids, it had a binding affinity of -9.1Kcal/mol, while that of conivaptan was -8.2Kcal/mol, and azelastine at -7.9Kcal/mol.

In addition, due to the reported side effects of the medicines, including blood and lymphatic system disorders, the researchers believe that functional foods would be safer.

On the other hand, fatty acids have the weakest affinity.

“Fatty acids without the ring structure showed the poorest affinity with the main protease of SARS-CoV-2. The docking affinity might increase with the numbers of rings and double bonds of ligands,”​ the researchers said.

The implication of the finding is that ligands such as quercetin could potentially affect the functionality of the COVID-19 virus.  This is, however, a hypothesis which needs to be proven in actual experiments, he added.

Also, since the main protease of COVID-19 showed some level of affinity with several nutrients, the researchers also hypothesised that it would consume these nutrients, in turn, damaging the body.

“It should be further considered whether the exogenous nutrients should be provided to slow, halt, or reverse biochemical alterations and structural deterioration in our body,”​ the researchers said.

Regional food focus

On the present project, Dr Li said he would focus on screening the ligands of regional food raw materials.

Examples include wolfberry commonly used in Chinese cuisine and the golden oyster mushroom (pleurotus citrinopileatus).

“Ever since the previous study was published, we have received good feedback and interest from collaborating companies and other researchers, which is why we have decided to continue the screening,”​ he said.

“The point of the work is not to find the treatment for COVID-19 but more of finding an adjuvant therapy.”

The one million ligands that would be screened do not include those from the previous research.

As for the prospects of conducting human clinical trials, he said that this would be much further down the road, since lab and animal experiments needed to be conducted first.

 

Source: Journal of Food Biochemistry

Virtual screening for functional foods against the main protease of SARS-CoV-2

DOI: 10.1111/jfbc.13481

Authors: Jiao Wang, Xiaoli Zhang, Alejandra B. Omarini, and Binglin Li

Related news

Show more

Related products

show more

Naturally stable astaxanthin for healthy aging

Naturally stable astaxanthin for healthy aging

Lipofoods, a Lubrizol Company | 16-Oct-2020 | Product Presentation

In this video, the Nutraceuticals Division of Lubrizol Life Science Health presents ASTAGILE™ microcapsules, a natural, stable microencapsulated astaxanthin...

A wish come true for the allergy prone

A wish come true for the allergy prone

Indena | 21-Sep-2020 | Technical / White Paper

New research has confirmed that Indena’s Quercefit™ - quercetin Phytosome® - is an effective natural remedy promoting wellbeing in sensitive or intolerant...

Robuvit® Boosts Recovery Following Surgery

Robuvit® Boosts Recovery Following Surgery

Horphag Research | 14-Sep-2020 | Clinical Study

New research found Robuvit® French oak extract improves general health, mood and social functioning of post-surgery patients. Robuvit®’s antioxidative...

MenaQ7® Vitamin K2: The Bone Support Solution

MenaQ7® Vitamin K2: The Bone Support Solution

NattoPharma USA, Inc. | 03-Sep-2020 | Data Sheet

Whether creating a product to fortify children’s bones as they grow or a formula to help adults stave off inevitable bone loss from ageing, MenaQ7® Vitamin...

Related suppliers

Follow us

Products

View more

Webinars

Nutra Champions Podcast

Nutra Champions Podcast